Cognitive performance tracked plasma β-hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels, compared with predose levels. The KME was well tolerated throughout the 20-month treatment period. The patient improved markedly in mood, affect, self-care, and cognitive and daily activity performance. Limitations of dietary methods currently used to produce therapeutic hyperketonemia have stimulated the search for better approaches.ĭescribed herein is a new way to produce therapeutic hyperketonemia, entailing prolonged oral administration of a potent ketogenic agent-ketone monoester (KME)-to a patient with Alzheimer's disease dementia and a pretreatment Mini-Mental State Examination score of 12. For this, plasma ketones must be elevated well above the ≤ 0.2 mM default concentrations normally prevalent. Providing ketone bodies to the brain can bypass metabolic blocks to glucose utilization and improve function in energy-starved neurons.
0 Comments
Leave a Reply. |